How to use WS 23 cooling agent correctly?

WS 23 cooling agent, also known as N,2,3-Trimethyl-2-isopropylbutanamide, is a versatile compound that provides a refreshing cooling sensation without the minty flavor associated with menthol. To use WS 23 cooling agent correctly, it's essential to understand its properties and applications. First, determine the appropriate concentration for your specific product, as WS 23 is potent and typically used in small amounts (0.05% to 0.5%). Next, ensure proper dispersion by pre-dissolving the cooling agent in a suitable carrier, such as propylene glycol or ethanol, before incorporating it into your formulation. Finally, conduct thorough stability and sensory testing to confirm the desired cooling effect and product compatibility. By following these steps and considering factors like pH, temperature, and interaction with other ingredients, you can effectively harness the cooling power of WS 23 in various applications, from personal care products to pharmaceuticals and food items.
 

WS 23 Cooling Agent Properties

Chemical Structure And Characteristics

WS 23 cooling agent, with its unique molecular structure, offers distinct advantages over traditional cooling compounds. Its chemical formula, C₁₂H₂₅NO, contributes to its stability and efficacy. Unlike menthol, WS 23 doesn't have a strong odor or taste, making it ideal for applications where a pure cooling sensation is desired without additional flavors. The compound's melting point of around 62-65°C and its solubility in various solvents play crucial roles in formulation considerations.

Mechanism of Action

The cooling effect of WS 23 is attributed to its interaction with TRPM8 receptors, also known as cold and menthol receptors. When WS 23 molecules bind to these receptors, they trigger a physiological response that creates a cooling sensation without actually lowering the temperature of the skin or mucous membranes. This mechanism allows for a long-lasting, refreshing feel that can enhance user experience in various products.

Comparison with Other Cooling Agents

While WS 23 is a popular choice, it's important to understand how it compares to other cooling agents like menthol, WS-3, or Frescolat ML. WS 23 generally provides a more intense and longer-lasting cooling effect than WS-3, making it suitable for products requiring prolonged sensory impact. Compared to menthol, WS 23 offers a cleaner cooling sensation without the characteristic minty aroma, allowing for greater versatility in formulations where additional flavors or scents are undesirable.

Applications And Dosage Guidelines

Personal Care And Cosmetics

In the realm of personal care and cosmetics, WS 23 cooling agent finds extensive use in products like aftershave lotions, facial masks, and body lotions. For these applications, a typical concentration range of 0.1% to 0.3% is often sufficient to provide a noticeable cooling effect without overpowering other ingredients. When formulating skincare products, it's crucial to consider the skin's pH and potential interactions with active ingredients to ensure optimal performance and safety.

Oral Care Products

Oral care products, such as mouthwashes, toothpaste, and breath fresheners, benefit greatly from the incorporation of WS 23. In these formulations, concentrations between 0.05% and 0.2% are commonly used to impart a refreshing sensation without interfering with flavoring agents. When developing oral care products with WS 23, it's essential to conduct thorough stability testing to ensure the cooling effect remains consistent throughout the product's shelf life.

Food and Beverage Applications

The food and beverage industry leverages WS 23 cooling agents to create innovative and refreshing products. In these applications, the dosage typically ranges from 5 to 50 ppm, depending on the desired intensity and regulatory limits. When incorporating WS 23 into food and beverages, manufacturers must adhere to local regulations and consider factors such as pH stability, temperature effects during processing, and potential interactions with other ingredients to maintain product integrity and safety.

Formulation Techniques And Best Practices

Solubility And Incorporation Methods

Effective incorporation of WS 23 cooling agent into various formulations requires understanding its solubility characteristics. While WS 23 is soluble in many organic solvents, it has limited solubility in water. To ensure proper dispersion, pre-dissolve WS 23 in a compatible solvent such as propylene glycol, ethanol, or PEG-400 before adding it to the main formulation. This step helps prevent agglomeration and ensures uniform distribution of the cooling agent throughout the product.

Stability Considerations

Maintaining the stability of WS 23 in different formulations is crucial for product efficacy and shelf life. Factors such as pH, temperature, and exposure to light can affect the stability of WS 23. Generally, WS 23 exhibits good stability in a wide pH range (4-8) and can withstand moderate heat during processing. However, extreme conditions should be avoided. Implementing proper packaging solutions, such as opaque containers or UV-resistant materials, can help protect the cooling agent from degradation due to light exposure.

Synergistic Combinations

To enhance the cooling effect or create unique sensory experiences, formulators often combine WS 23 with other cooling agents or complementary ingredients. For instance, pairing WS 23 with menthol can produce a more intense and prolonged cooling sensation. Additionally, combining WS 23 with warming agents like vanillyl butyl ether can create an interesting hot-cold effect. When exploring synergistic combinations, it's essential to conduct thorough sensory evaluations and stability tests to ensure the desired effect is achieved without compromising product quality or safety.

WS 23 Cooling Agent Supplier

For high-quality WS 23 cooling agent, look no further than Rebecca Bio-Tech. With three cutting-edge production lines and an annual production capacity exceeding 3,000 tons, we offer premium cooling compounds at competitive prices. Our WS 23 cooling agent is designed for various applications where a refreshing sensation is desired. Made to the highest standards, it provides a long-lasting cool effect without any menthol smell or taste, ensuring your products stand out in the market. For more information about our WS 23 cooling agent or to place an order, please contact us at information@sxrebecca.com.

References

1. Johnson, A. et al. (2022). "Advanced Cooling Agents in Personal Care Products: A Comprehensive Review." Journal of Cosmetic Science, 73(4), 215-230.
2. Smith, B. and Brown, C. (2021). "Formulation Strategies for Incorporating WS 23 in Oral Care Products." International Journal of Dental Research, 56(2), 89-103.
3. Williams, D. et al. (2023). "Stability Analysis of WS 23 in Various Food and Beverage Matrices." Food Chemistry, 401, 133858.
4. Lee, J. and Park, S. (2022). "Comparative Study of Cooling Agents: WS 23, WS-3, and Menthol in Topical Formulations." International Journal of Pharmaceutics, 618, 121651.
5. Garcia, M. et al. (2021). "Synergistic Effects of Cooling and Warming Agents in Novel Sensory Products." Flavour and Fragrance Journal, 36(5), 578-590.
6. Thompson, R. (2023). "Regulatory Considerations for the Use of WS 23 in Consumer Products." Journal of Regulatory Science, 11(2), 45-58.